Ototoxicity of Acetylsalicylic Acid
- 1 February 1965
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 81 (2) , 134-138
- https://doi.org/10.1001/archotol.1965.00750050141006
Abstract
ASPIRIN (acetylsalicylic acid) is generally regarded as one of the safest drugs. It is widely used by the layman and freely prescribed by all physicians. It is thought that about 9 million pounds of aspirin alone are consumed yearly in the United States.1 As early as 1922, Pohlman and Kranz2 were experimenting in St. Louis with the effects of quinine, aspirin, and other salicylates on the hearing mechanism. They were handicapped in that they were able to measure their subjects' hearing only crudely. They concluded that although these drugs produced a definite decrease in hearing, recovery occurred in approximately 24 hours. It is generally known that large doses of salicylates have a toxic effect on the ear, though the exact mechanism of action on the ear is not known. Salicylates3 are known to produce tinnitus, hearing loss, and vertigo. The continuing use of large doses of salicylatesKeywords
This publication has 1 reference indexed in Scilit:
- ASPIRIN ALLERGY: ITS RELATIONSHIP TO CHRONIC INTRACTABLE ASTHMAAnnals of Internal Medicine, 1947