Murine enterocytes can present soluble antigen to specific class II‐restricted CD4+ T cells
- 31 July 1989
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 19 (8) , 1513-1516
- https://doi.org/10.1002/eji.1830190827
Abstract
Highly purified mature epithelial cells (EC) from murine small intestinal villi (excluding Peyer's patch epithelium) were examined for their capacity to present foreign antigen to T cells. Cell suspensions composed of 99% Ia+T200‐ EC were able to present keyhole limpet hemocyanin to an antigen‐specific class II‐restricted L3T4+ T cell hybridoma, and stimulate interleukin 2 production. Antigen presentation by EC was inhibited by major histocompatibility complex class II‐specific monoclonal antibodies. It is concluded that EC express functional class II molecules and may activate adjacent CD4+ T cells to induce lymphokine synthesis.This publication has 12 references indexed in Scilit:
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