Effect of various proteinase inhibitors on ovulation of explanted hamster ovaries

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Abstract
Hamster ovaries explanted at 2100-2400 h on the day of proestrus were incubated with microbial proteinase inhibitors until 1030 h on the next morning and the ovulatory blocking effect of these inhibitors was examined. Among 11 proteinase inhibitors examined, talopeptin, a specific inhibitor for metalloproteinases, and .alpha.-MAPI [microbial alkaline proteinase inhibitor] a specific inhibitor for serine and thiol proteinases, were the strongest blockers. These 2 inhibitors exhibited a chronological discrepancy in their blocking effect on ovulation. S-SI [Streptomyces subtilisin inhibitor] plasminostreptin, elastatinal, antipain and chymostatin, which are inhibitors for serine proteinases, partly but significantly inhibited ovulation. In addition to a metalloproteinase reported previously, a proteinase which is sensitive to .alpha.-MAPI is essential for the ovulatory process; serine proteinase(s) also participate in ovulation of the hamster ovary.

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