Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene
Open Access
- 1 August 2000
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 267 (16) , 5191-5197
- https://doi.org/10.1046/j.1432-1327.2000.01588.x
Abstract
Clostridium perfringens phospholipase C (PLC), also called α‐toxin, is the major virulence factor in the pathogenesis of gas gangrene. The toxic activities of genetically engineered α‐toxin variants ...Keywords
This publication has 55 references indexed in Scilit:
- Characterisation of the calcium-binding C-terminal domain of Clostridium perfringens alpha-toxin 1 1Edited by A KlugJournal of Molecular Biology, 1999
- Lipids protein-lipid interactions on the surfaces of cell membranesCurrent Opinion in Structural Biology, 1999
- Structure of the key toxin in gas gangreneNature Structural & Molecular Biology, 1998
- Clostridial Gas Gangrene: Evidence That α and θ Toxins Differentially Modulate the Immune Response and Induce Acute Tissue NecrosisThe Journal of Infectious Diseases, 1997
- Characterization and modeling of membrane proteins using sequence analysisCurrent Opinion in Structural Biology, 1995
- Gramicidin and gramicidin-lipid interactionsBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1992
- The function of tryptophan residues in membrane proteinsProtein Engineering, Design and Selection, 1992
- Improved methods for building protein models in electron density maps and the location of errors in these modelsActa Crystallographica Section A Foundations of Crystallography, 1991
- Suggestions for “safe” residue substitutions in site-directed mutagenesisJournal of Molecular Biology, 1991
- Monoclonal antibodies against alpha toxin of Clostridium perfringensFEMS Microbiology Letters, 1989