Synthesis of antimicrobial agents. VII. Synthesis and antibacterial activities of furo(2,3-g)quinoline derivatives.
- 1 January 1984
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 32 (12) , 4923-4928
- https://doi.org/10.1248/cpb.32.4923
Abstract
As part of a series of studies on the synthesis of new antibacterial agents, tetracyclic compounds having a furo[2,3-g]quinoline moiety as a common structural unit were synthesized and their antibacterial activities were examined. Among them, 3-methyl-7-oxo-2,3-dihydro-7H-furo[2,3-h]pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid exhibited the most potent antibacterial activity against Gram-positive and -negative organisms [Escherichia coli, Shigella flexneri, Salmonella typhimurium, Proteus vulgaris, P. mirabilis, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pyogenes], and it showed low acute toxicity to mice.This publication has 1 reference indexed in Scilit:
- Synthesis of antimicrobial agents. III. Synthesis and antimicrobial activities of thiazolo[5,4-b]naphthyridine derivatives.CHEMICAL & PHARMACEUTICAL BULLETIN, 1979