Effect of Methysergide and Pimozide on Apomorphine-Induced Growth Hormone Secretion in Men
- 1 April 1977
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 44 (4) , 766-770
- https://doi.org/10.1210/jcem-44-4-766
Abstract
The dopamine receptor agonist, apomorphine hydrochloride (0.75 mg s.c.) increased serum growth hormone (GH) concentrations in each of 6 subjects. This increase was not inhibited by pretreatment with the serotonin antagonist, methysergide, but was completely abolished in the 4 individuals pretreated with pimozide, a selective dopamine receptor blocking agent. Further evidence that apomorphine-induced GH secretion is mediated by a dopaminergic mechanism and is independent of a serotonergic mechanism.This publication has 1 reference indexed in Scilit:
- Growth hormone response to D-amphetamine in normal controls and in depressive patientsNeuroscience Letters, 1975