Disease‐specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain
Open Access
- 1 September 2003
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 17 (14) , 2014-2024
- https://doi.org/10.1096/fj.03-0205com
Abstract
Molecular misreading of the ubiquitin-B (UBB) gene results in a dinucleotide deletion in UBB mRNA. The resulting mutant protein, UBB+1, accumulates in the neuropathological hallmarks of Alzheimer dis...Keywords
Funding Information
- International Brain Research Organization
- Hersenstichting (H00.06)
- Internationale Stichting Alzheimer Onderzoek
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
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