Singular Spectrum Analysis of Gene Expression Profiles of EarlyDrosophila embryo: Exponential-in-Distance Patterns
Open Access
- 20 July 2008
- journal article
- research article
- Published by Hindawi Limited in Research Letters in Signal Processing
- Vol. 2008, 1-5
- https://doi.org/10.1155/2008/825758
Abstract
We present investigation of gene expression profiles by means of singular spectrum analysis (SSA). The biological problem under investigation is the decomposition ofbicoidprotein profiles ofDrosophila melanogasterinto the sum of a signal and noise, where the former consists of an exponential-in-distance pattern and is close to constant nonspecific component, or “background.” The signal processing problems addressed are (i) trend extraction from a noisy signal, (ii) batch processing of similar data, and (iii) analytical approximation of the signal components by the sum of exponential and constant-like functions. The proposed methods are evaluated on the given 17 series.Keywords
Funding Information
- National Institute of General Medical Sciences (1-R01-GM072022, RUB1-1643-ST-06)
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