Trisodium Nitrilotriacetate in Drinking Water

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Abstract
Trisodium nitrilotriacetate (Na-NTA) at either 0.01%, 0.10%, or 1% (W/V) was given to rats in drinking water with or without 200μg lead (Pb) per milliliter. At the 1% Na-NTA level, rats became ill and were autopsied after four weeks of the experiment. These rats had a vacuolar tubular nephropathy, hyperglycemia, and a marked glycosuria. Rats given 0.01% and 0.10% Na-NTA with or without Pb displayed no histologic changes in kidney, liver, brain, or pancreas but had elevated blood glucose levels. The Na-NTA atone lowered Pb content of kidneys, whereas Na-NTA with Pb did not enhance Pb deposition in kidney. The hyperglycemic effect of Na-NTA was confirmed in a second strain of rats. The mechanism whereby Na-NTA influenced blood glucose levels is unknown but may relate to trace metal chelation.

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