Progressive Multifocal Leukoencephalopathy and Natalizumab — Unforeseen Consequences
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- 28 July 2005
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 353 (4) , 414-416
- https://doi.org/10.1056/nejme058122
Abstract
In this issue of the Journal, there are reports describing in detail three patients in whom progressive multifocal leukoencephalopathy (PML) developed during treatment with natalizumab, a humanized monoclonal antibody against α4 integrins.13 These patients were among 3000 who had participated in clinical trials of natalizumab for the treatment of multiple sclerosis or Crohn's disease. PML is a deadly opportunistic infection of the central nervous system (CNS) for which there is no specific treatment. It is caused by reactivation of a clinically latent JC polyomavirus infection. This virus infects and destroys oligodendrocytes, leading to multifocal areas of demyelination and . . .Keywords
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