The effect of the photodecomposition of chlorpromazine on lecithin monolayers
- 1 September 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 30 (1) , 748-753
- https://doi.org/10.1111/j.2042-7158.1978.tb13385.x
Abstract
Chlorpromazine hydrochloride (cpz) is decomposed when irradiated with ultraviolet light, forming H+, hydrochloric acid, chlorpromazine sulphoxide and 2-hydroxypromazine. The order of the reaction (as measured by the expansion that is produced in a lecithin/cpz monolayer) varies between zero and about 3/4. The results have been used to explain some of the adverse side effects that are observed when patients are treated with cpz.This publication has 18 references indexed in Scilit:
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