Proton-Magnetic-Resonance Study of Copper(I) Complexes with Peptides Containing Sulfhydryl and Imidazole Groups as Possible Model Ligands for Copper Proteins
- 1 September 1977
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 78 (2) , 431-435
- https://doi.org/10.1111/j.1432-1033.1977.tb11755.x
Abstract
The Cu(I) complexes of peptides containing sulfhydryl and imidazole groups were investigated in aqueous solution by 1H NMR. The N-mercaptoacetyl-L-histidine coordinates through the sulfhydryl S and imidazole N atoms to form the unique 1:1 Cu(I) complex species containing bridged imidazole. The sulfhydryl and imidazole groups are adequate ligands for not only Cu(II) but also Cu(I). The 1H NMR spectra show that the peptide N group is not involved in complex formation of Cu(I) with N-mercaptoacetyl-L-histidine and 3-mercaptopropionyl-L-histidine. The results were discussed with respect to the protein ligands for blue Cu centers.This publication has 17 references indexed in Scilit:
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