Nuclear ADP-ribosyl transferase activity correlates with induction of P-450 monooxygenases by phenobarbital in rat liver microsomes
- 1 September 1985
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 151 (3) , 621-624
- https://doi.org/10.1111/j.1432-1033.1985.tb09149.x
Abstract
The effect of phenobarbital treatment on the nuclear ADP-ribosyltransferase activity has been studied in parallel with microsomal cytochrome P-450 concentration and related mono-oxygenase activities, in rat liver. A marked activation of the ADP-ribosyltransferase was observed 24 h after phenobarbital administration. The chronological study performed between 0-6 days after phenobarbital treatment showed a sharp increase in this nuclear enzyme activity, to .apprxeq. 270% of the control value produced in 48 h. The administration of 5''-methylnicotinamide in vivo, an inhibitor of ADP-ribosyltransferase activity in vitro, produced a decrease both of the induction of liver microsomal cytochrome P-450 mono-oxygenases and nuclear ADP-ribosyltransferase activity. The role of nuclear ADP-ribosyltransferase in the adaptative response of the liver cell to phenobarbital is discussed.This publication has 27 references indexed in Scilit:
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