Aspergillus Antibody in Patients With Cystic Fibrosis

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Abstract
• The respiratory flora of patients with cystic fibrosis (CF) frequently includesAspergillus, and 30% of their serum samples have been observed to contain precipitating antibody to this fungus. Serum from 61 CF patients, 60 healthy persons, and three patients with CF and allergic bronchopulmonary aspergillosis was studied, using a quantitative assay for antibody toA fumigatus. Although CF patients had significantly higher levels ofAspergillusantibody, some antibody was found in all serum samples from normal individuals. Binding was immunologically specific forA fumigatus. Serum IgE levels and dermal reactivity toAspergilluswere similar in both CF and normal subjects. Increased levels ofAspergillusantibody in CF patients probably reflect pulmonary colonization, which only rarely causes infection or sensitization. (Am J Dis Child129:1164-1167, 1975)