LONG-TERM, AMBULATORY, CONTINUOUS IV INFUSION OF 5-FU FOR THE TREATMENT OF ADVANCED ADENOCARCINOMAS

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 69  (1) , 13-15
Abstract
Patients (23) with metastatic adenocarcinomas were treated with long-term, continuous, ambulatory i.v. infusion of 5-fluorouracil. Length of infusion was 54-324 days. The usual daily dose was 300 mg/m2. Toxicity was primarily stomatitis. Hand/foot syndrome occurred in 11 patients. Nausea, vomiting myelosuppression and alopecia were not observed. Thirteen patients had stomatitis. Eighteen patients had evaluable lesions; 8 achieved partial response, 5 had stable disease and 5 had progressive disease. Further studies are necessary to confirm the level of tumor response and survival period of patients treated with this method.