In May, 1916, I1proposed a regimen of nonsurgical management for selected instances of peptic ulcer (gastric and duodenal). It attempted to aline nonsurgical management with the facts which investigations in the clinical course, pathology, bacteriology and physiology of peptic ulcer had made available. To summarize, I emphasized that: In more than 95 per cent, of instances, peptic ulcer is a visceral lesion formed as a complication of a systemic, constitutional, toxic or environmental disturbance. A fundamental step in therapy demands recognition of the possible causative factors and an attempt at their eradication or alleviation, irrespective of any form of treatment to the visceral lesion; this necessitates intensive analysis of each ulcer subject. The clinical symptomatology of peptic ulcer depends largely on the manifestations of abnormal gastric and duodenal motor activity rather than on unphysiologically altered digestive chemism. Healing of peptic ulcer is facilitated best by assuring rest to