Ventilatory responses to embolization of lung

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Abstract
Marked changes in respiratory rate and volume occurred when anesthetized and spontaneously breathing dogs were subjected to pulmonary embolization with barium sulfate. Following embolization, there was a statistically significant fall in lung compliance, and, although a rise in pulmonary air-flow resistance occurred in the majority of instances, this change was not statistically significant. When the dogs were ventilated in approximately the resting tidal range by means of a pump and embolization was carried out, a statistically significant fall in lung compliance as well as a significant rise in pulmonary resistance was seen. Embolization of spontaneously breathing vagotomized animals in three instances revealed a fall in lung compliance and a rise in pulmonary resistance. The experimental observations of others are reviewed and the clinical implications are discussed. Submitted on October 28, 1960

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