Synthesis of arabinofuranosyl derivatives of 3-deazaguanine
- 1 August 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (8) , 958-962
- https://doi.org/10.1021/jm00194a014
Abstract
Synthesis of 4 arabinofuranosyl derivatives of the antitumor agent 3-deazaguanine is described. By the use of 13C and 1H NMR spectroscopy, the structures of these nucleosides were established to be .alpha. and .beta. pairs of N-7 and N-9 arabinosides of 3-deazaguanine. In contrast to 3-deazaguanine and its ribosyl derivative, the nucleosides described were inactive against Sarcoma 180 in mice at 100 mg/kg.This publication has 0 references indexed in Scilit: