PROLIFERATIVE EPITHELIAL LESIONS OF URINARY-BLADDER IN CYNOMOLGUS MONKEYS (MACACA-FASCICULARIS) INFECTED WITH SCHISTOSOMA-INTERCALATUM

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (8) , 2928-2931
Abstract
Five cynomolgus monkeys (M. fascicularis) were infected with S. intercalatum, a helminth that is morphologically similar to S. haematobium. Infections were readily established and remained active until the monkeys were sacrificed 21-84 wk after exposure. Although the schistosomes were located predominantly in mesenteric and hepatic portal venules, schistosome eggs were found in the bladders of 3 monkeys. Nodules of atypical epitheial cells interpreted as superficially infiltrating undifferentiated bladder carcinomas were found in 1 monkey 23 wk after infection. These sessile tumors differ from the well-differentiated, papillary transitional cell tumors previously reported from several species of experimental animals infected with S. haematobium. The tumors are also dissimilar to the squamous cell bladder tumors associated with S. haematobium infection in man but may be useful for investigations of schistosomal bladder cancer.

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