COMBINATIONS OF 5-FU, HYPOXANTHINE, AND ALLOPURINOL IN CHEMOTHERAPY FOR HUMAN-COLON ADENOCARCINOMA XENOGRAFTS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 66  (5) , 1201-1206
Abstract
A series of 4 human colon adenocarcinomas, growing as xenografts in immune-deprived mice, were used to evaluate the efficacy of 5-FU in combination with 2 purines, hypoxanthine (Hx) and allupurinol (HPP), which have reduced the toxicity of 5-FU in host mice. Tumor-bearing mice were treated at 7-day intervals with 5-FU administered simultaneously with the protecting agents (Hx and HPP). Two tumor lines (HxVRC5 and HxGC3), insensitive to 5-FU alone, failed to show any response to this combination. In 5-FU-sensitive HxELC2 tumors, the combination of 5-FU with Hx and HPP did not increase the therapeutic index, and in HxHC1 xenografts, antagonism to 5-FU cytotoxicity was observed. Tumor response in relation to the pathways of 5-FU metabolism is discussed.