Binding of an Antiviral Agent (Kethoxal) by Various Metabolites

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Abstract
[beta]-Ethoxy-[alpha]-ketobutyraldehyde hydrate (Kethoxal) was markedly active as an antiviral agent in eggs but did not show significant antiviral activity in animals. Kethoxal reacted chemically with normal metabolites to give products of varying antiviral activity e.g., reaction with cysteine or arginine resulted in rapid loss of antiviral activity, with glycine or intact protein in more gradual loss of activity, whereas reaction with serine or threonine gave products with undiminished antiviral activity. Lack of activity by Kethoxal in animals was apparently due to its rapid binding and inactivation by proteins, amino acids, and some other metabolites.

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