CHARACTERISTICS OF THE STIMULUS PRODUCED BY THE MIXTURE OF CANNABIDIOL WITH DELTA-9-TETRAHYDROCANNABINOL

  • 1 January 1981
    • journal article
    • research article
    • Vol. 249  (1) , 137-146
Abstract
Rats, trained to discriminate between .DELTA.9-THC [.DELTA.9-tetrahydrocannabinol] (5 mg/kg) and a control solution, using a T-maze, were submitted to generalization tests with .DELTA.9-THC (2.5 and 1.25 mg/kg), CBD [cannabidiol] (40 mg/kg) and the mixtures of .DELTA.9-THC (5 and 1.25 mg/kg) with CBD (40 mg/kg). Doses of .DELTA.9-THC smaller than the training dose, produced a progressive reduction in the number of correct responses together with a decrease in the running time. The choice made by the animals under the effect of CBD (40 mg/kg) did not differ from that of the animals given the control solution, but their running time was significantly longer. The mixtures of CBD (40 mg/kg) with .DELTA.9-THC (5 and 1.25 mg/kg) produced .apprx. 50% response to both sides of the maze, and run times greater than those observed with .DELTA.9-THC (5 mg/kg). The simultaneous administration of the 2 cannabinoids might produce a qualitative stimulus different from that produced by .DELTA.9-THC alone.

This publication has 1 reference indexed in Scilit: