Pharmacological actions of baicalin and baicalein

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Abstract
In the previous paper, the authors reported about the action of baicalin and baicalein on active anaphylaxis. In the present series of experiments, the action of these substances on passive anaphylaxis was examined and the following results were obtained. 1) The symptom caused by passive systemic anaphylaxis (PSA) was inhibited by emamined substances. In glycoside, the inhibitory effect of baicalin was more potent than those of rutin and methylhesperidin, and in aglycone, baicalein was more potent than quercetin. Furthermore, the effect of aglycone was more potent than that of corresponding glycoside. 2) The inhibitory effect of examined substances on PSA in guinea pigs was more effective in the case of administration at 2 hrs prior to challange than in that at 2 hrs and 24 hrs by dividing into two equal parts. 3) On the PSA in mice, all examined substances sligtly showed inhibitory effect. 4) By the intraperitoneal administration of examined substances, passive cutaneous anaphylaxis (PSA) in guinea pigs was inhibited in the following order; baicalein>rutin>baicalin≈methylhesperidin>quercetin>control. And also inhibited by the intradermal administration combined with antiserum, but the order of inhibition was shifted as follows; baicalein>methylhesperidin>quercetin>rutin>baicalin≈control. 5) The cutaneous response induced with histamine was inhibited by the examined substances in the following order; baicalein>baicalin≈rutin>methylhesperidin≈control>quercetin.

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