Revival of Tubercle Bacilli After Prolonged in vitro Exposure to Isoniazid
- 1 April 1954
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 85 (4) , 538-540
- https://doi.org/10.3181/00379727-85-20943
Abstract
Hemin, K ferricyanide, and pyruvate are reversing agents for isoniazid; in their presence, killing of the H37Rv strain of Mycobacterium tuberculosis var. hominis was not accomplished after 5 wks. of exposure to 1000 [mu]g. isoniazid/ml. As little as 0.6 [mu]g hemin/ml accomplished such reversal, and revived cells were still isoniazid sensitive. Although these expts. employed resting cells, similar results were obtained with growing tubercle bacilli.Keywords
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