EFFECTS OF HYDROCORTISONE ACETATE ON PULMONARY ALVEOLAR MACROPHAGE COLONY-FORMING CELLS

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Abstract
Effect of proloned monocytopenia, induced by daily injections of hydrocortisone acetate, on the number of alveolar cells and alveolar macrophage colony-forming cells (AL-CFC) was investigated in mice. There was no appreciable reduction in the number of alveolar macrophages or AL-CFC under this experimental condition, which markedly inhibited the blood monocyte concentration over 10 days. Apparently, a mechanism exists by which the number of alveolar macrophages, including Al-CFC, can be maintained without a continuous migration of blood monocytes into alveolar spaces.

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