Lack of Detectable Reverse Transcriptase Activity in Human and Chimpanzee Sera with a High Infectivity for Non-A, Non-B Hepatitis
- 1 April 1986
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 67 (4) , 777-779
- https://doi.org/10.1099/0022-1317-67-4-777
Abstract
A serum sample from a patient with hepatitis and samples from two experimentally infected chimpanzees, all with a high infectivity for non-A, non-B hepatitis, were tested for reverse transcriptase. Biopsy confirmed that the hepatocytes of the chimpanzees that received these sera contained the characteristic tubular structures associated with non-A, non-B hepatitis. None of these three sera revealed detectable enzyme activity. We have not been able to confirm the association of reverse transcriptase activity with non-A, non-B hepatitis reported recently.This publication has 6 references indexed in Scilit:
- DETECTION OF REVERSE TRANSCRIPTASE ACTIVITY IN ASSOCIATION WITH THE NON-A, NON-B HEPATITIS AGENT(S)The Lancet, 1984
- Non-A, Non-B (Type 1) Hepatitis Agent Capable of Inducing Tubular Ultrastructures in the Hepatocyte Cytoplasm of Chimpanzees: Inactivation by Formalin and HeatGastroenterology, 1982
- Demonstration of two different types of non-A, non-B hepatitis by reinjection and cross-challenge studies in chimpanzeesGastroenterology, 1981
- Viruslike particles in a plasma fraction (fibrinogen) and in the circulation of apparently healthy blood donors capable of inducing non-A/non-B hepatitis in humans and chimpanzeesGastroenterology, 1980
- Transfusion-Transmitted Viruses Study: Experimental Evidence for Two Non-A, Non-B Hepatitis AgentsThe Journal of Infectious Diseases, 1980
- Non-A, Non-B Hepatitis: Ultrastructural Evidence for Two Agents in Experimentally Infected ChimpanzeesScience, 1979