Molecular Mechanisms of Resistance to Tamoxifen Therapy in Breast Cancer
- 1 November 1993
- journal article
- review article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 128 (11) , 1187-1191
- https://doi.org/10.1001/archsurg.1993.01420230015002
Abstract
Clinical data suggest that the use of adjuvant tamoxifen citrate (Nolvadex) for a minimum of 5 years, and possibly indefinitely, will result in maximal antitumor benefit. There is concern that long-term tamoxifen maintenance therapy may result in the induction of drug resistance. This article reviews the potential molecular mechanisms of resistance to tamoxifen and explores the possibility of tamoxifen-stimulated tumor growth. (Arch Surg. 1993;128:1187-1191)Keywords
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