The Identification of Metabolic Errors Associated With Hemolytic Anemia

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Abstract
Hemolytic anemia or potentially hemolytic disorders due to metabolic errors of the erythrocyte are being recognized with increasing frequency. These disorders are characterized either by congenital nonspherocytic hemolytic anemia or by drug-inducible hemolysis. For identification of such disorders, most clinical laboratories will find it expedient to depend primarily on simple, specific screening tests which usually permit a precise etiologic diagnosis to be established as reliably as, and more economically than, by more tedious quantitative assays. The specific screening tests can be satisfactorily performed in laboratories with limited facilities. A test for peroxidative denaturation of hemoglobin is very sensitive, but nonspecific, and may be useful in screening for a variety of metabolic defects and for some of the unstable hemoglobinopathies. In unexplained cases of congenital nonspherocytic hemolytic anemia, a thermolability test should be performed for unstable hemoglobin.

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