Hydraulic Permeability of Polyglycolic Acid Scaffolds as a Function of Biomaterial Degradation
- 1 January 2005
- journal article
- research article
- Published by SAGE Publications in Journal of Biomaterials Applications
- Vol. 19 (3) , 253-266
- https://doi.org/10.1177/0885328205047219
Abstract
Using a simple experimental setup, the hydraulic permeability of fibrous nonwoven polyglycolic acid (PGA) scaffolds is studied after different degradation durations in PBS. The hydraulic permeability of the scaffolds increased with the degradation time. After being incubated for about 4 weeks, the permeability of the scaffold begins to drop. It is noted that the PGA scaffold apparently begins to contract and cannot maintain its original shape after 4 weeks of degradation. These results underpin the understanding of the biotransport processes in the scaffolds during tissue engineering experiments.Keywords
This publication has 13 references indexed in Scilit:
- Morphological and biomechanical characterization of poly(glycolic acid) scaffolds after in vitro degradationPolymer Degradation and Stability, 2003
- Biodegradable polymeric scaffolds for musculoskeletal tissue engineeringJournal of Biomedical Materials Research, 2001
- Effects of fluid flow on the in vitro degradation kinetics of biodegradable scaffolds for tissue engineeringBiomaterials, 2000
- In vitro growth and activity of primary chondrocytes on a resorbable polylactide three-dimensional scaffoldJournal of Biomedical Materials Research, 1999
- Biodegradable polymeric microcellular foams by modified thermally induced phase separation methodBiomaterials, 1999
- Development of biocompatible synthetic extracellular matrices for tissue engineeringTrends in Biotechnology, 1998
- The Effects of Porosity on in Vitro Degradation of Polylactic Acid–Polyglycolic Acid Implants Used in Repair of Articular CartilageTissue Engineering, 1998
- Novel approach to fabricate porous sponges of poly(d,l-lactic-co-glycolic acid) without the use of organic solventsBiomaterials, 1996
- Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/ polyglycolic acid copolymersBiomaterials, 1996
- Biodegradable polymers for use in surgery — poly(glycolic)/poly(Iactic acid) homo and copolymers: 2. In vitro degradationPolymer, 1981