Chemotherapeutic Studies with 2,4-Dimethoxy-6-sulfanilamido-1,3-diazine (Madribon)

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Abstract
This agent belongs to the group of compounds with prolonged persistence in the body (half life in the blood of rats: 48 hours). Low toxicity for mice, as shown by an LD50 of more than 10,000 mg/kg, was combined with marked antibacterial activity in vivo against 4 gram-positive organisms: Streptococcus pyogenes, Diplococcus pneumoniae, Micrococcus pyogenes var. aureus, Listeria monocytogenes and 8 gram-negative organisms, Neisseria meningitidis, Pasteurella multocida, Escherichia coli, Klebsiella pneumoniae, Salmonella schottmuelleri, Salmonella typhosa, Pseudomonas aeruginosa, Proteus vulgaris. The average CD50 was 46 to 49 mg/kg in the majority of the infections; only pneumococci and Pseudomonas required higher doses. The frequency of treatments could be reduced to one single oral administration in 7 of these infections. There was no convincing correlation between the activity in vivo and the bacteriostatic effect in vitro.

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