Polyploid Cells in Human Leukocytes Following in vivo and in vitro Irradiation

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Abstract
Incidence of polyploid cells were studied in leukocyte cultures established from radiation-exposed people, as well as from human blood irradiated in vitro with Co60 at dosages from 50R to 350R. Polyploid cells were more frequent in the radiation-exposed subjects than in normal ones. A high frequency of polyploid cells was also obtained in leukocytes cultured from blood irradiated in vitro. Frequency of polyploid cells increased with radiation dosage. The majority of the polyploid cells contained abnormal chromosomes, such as dicentrics, tricentrics, rings, and acentric fragments. Dicentrics occurred most frequently. Frequency of polyploid cells showing chromosome abnormalities increased with radiation dosage. Usually the abnormal chromosomes were present in single pairs, as a set of 2 morphologically identical chromosomes, in most cells in the tetraploid range; they occurred in 2 pairs in cells in the octoploid range. Evidence suggests that polyploid cells originate from cells with abnormal chromosomes which interfere with cell division, and the distribution of chromosomes to the daughter cells.

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