ROCK and Rho: Biochemistry and Neuronal Functions of Rho-Associated Protein Kinases
Open Access
- 1 October 2007
- journal article
- review article
- Published by SAGE Publications in The Neuroscientist
- Vol. 13 (5) , 454-469
- https://doi.org/10.1177/1073858407303611
Abstract
Rho-associated protein kinases (ROCKs) play key roles in mediating the control of the actin cytoskeleton by Rho family GTPases in response to extracellular signals. Such signaling pathways contribute to diverse neuronal functions from cell migration to axonal guidance to dendritic spine morphology to axonal regeneration to cell survival. In this review, the authors summarize biochemical knowledge of ROCK function and categorize neuronal ROCK-dependent signaling pathways. Further study of ROCK signal transduction mechanisms and specificities will enhance our understanding of brain development, plasticity, and repair. The ROCK pathway also provides a potential site for therapeutic intervention to promote neuronal regeneration and to limit degeneration. NEUROSCIENTIST 13(5):454—469, 2007.Keywords
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