Mechanism of Detoxication and Synergism of Bidrin Insecticide in House Flies and Soil1

Publisher Website
Google Scholar
Abstract
With C11-labeled Bidrin® insecticide (3-hydroxy-N,N-dimethyl-cis-croton-amide dimethyl phosphate), some studies have been made on its detoxication by house flies, Musca domestica L., and its stability in soil. House flies were treated topically with tagged Bidrin with and without the synergist sesamex. Two hours after treatment, the following effects were observed with synergist: increase in knockdown from 10 to 15% to nearly 100%; no significant effect on absorption; considerable reduction in the excretion of radioactive compounds; lower degree of metabolism of Bidrin; the absence of 1 route of metabolism. One of the metabolites found in a significant quantity in the absence of synergist, but very little when synergist was present, was identified as the highly toxic compound 3-hydroxy-N-methylcrotonamide dimethyl phosphate (SD 9129). Bidrin was quickly detoxified in soil. However, considerable stabilization of Bidrin in soil was observed when treated with 500 ppm of sesamex, chloropicrin, Nemagon® soil fumigant (l,2-dibromo-3-chloropropane), chloromycetin, acti-dione, Shell 345 Soil Fungicide® (diacetoxy propene) or O,O,O-trimethyl phosphorothioate (SD 4741). Detoxication of Bidrin was also greatly reduced in sterilized or “air dry” soil.

This publication has 4 references indexed in Scilit: