Fundamental issues in systems biology
Top Cited Papers
- 18 November 2005
- Vol. 27 (12) , 1270-1276
- https://doi.org/10.1002/bies.20323
Abstract
In the context of scientists' reflections on genomics, we examine some fundamental issues in the emerging postgenomic discipline of systems biology. Systems biology is best understood as consisting of two streams. One, which we shall call ‘pragmatic systems biology’, emphasises large‐scale molecular interactions; the other, which we shall refer to as ‘systems‐theoretic biology’, emphasises system principles. Both are committed to mathematical modelling, and both lack a clear account of what biological systems are. We discuss the underlying issues in identifying systems and how causality operates at different levels of organisation. We suggest that resolving such basic problems is a key task for successful systems biology, and that philosophers could contribute to its realisation. We conclude with an argument for more sociologically informed collaboration between scientists and philosophers. BioEssays 27:1270–1276, 2005.This publication has 84 references indexed in Scilit:
- Biological robustnessNature Reviews Genetics, 2004
- The evolution of molecular biology into systems biologyNature Biotechnology, 2004
- Community structure and metabolism through reconstruction of microbial genomes from the environmentNature, 2004
- Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis‐driven science in the post‐genomic eraBioEssays, 2003
- A vision for the future of genomics researchNature, 2003
- Functional genomics and proteomics as a foundation for systems biologyBriefings in Functional Genomics and Proteomics, 2003
- Systems Biology: A Brief OverviewScience, 2002
- Interrelating Different Types of Genomic Data, from Proteome to Secretome: 'Oming in on FunctionGenome Research, 2001
- A celebration and a farewellNature Genetics, 1997
- Loose endCurrent Biology, 1995