ARTIFICIAL HEMODIALYSIS IN MANAGEMENT OF GLUTETHIMIDE INTOXICATION

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Abstract
Two patients attempted suicide by taking glutethimide (Doriden). Although the amount did not exceed 15 Gm. in either case, both patients went gradually into deep coma. Artificial hemodialysis was commenced in each case after conservative methods, including use of stimulants and diuretics, had failed. In one patient visible improvement began within three hours. In the other, deglutition and some reflexes were normal after eight hours of hemodialysis, but coma continued and tracheotomy was necessary to prevent asphyxia. In the latter patient, rather abrupt and complete recovery from coma occurred next day, 20 minutes after a diagnostic lumbar puncture. Quantitative data obtained from this patient showed that the diuresis had removed only small amounts of glutethimide, whereas the artificial hemodialysis had removed at least 1,420 mg. of the drug at an almost constant rate of 150 mg. per hour.

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