Repopulation of Bone Marrow in Mice: Number and Type of Cells Required for Post-X-Irradiation Protection

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Abstract
Fractionation of cells from mouse bone marrow and autologous mouse spleen indicates that the cell responsible for bone marrow repopulation and X-irradiation protection resembles the small lymphocyte. Injection of different numbers of bone marrow and spleen cells and observations on survival obtained by fractional irradiation of the entire body and of extirpation of the shielded spleen after irradiation indicate that approximately 3 x 104 cells of this type are required to provide 50% survival. Approximately this number migrates from the shielded extremity or spleen of a mouse/hour (slightly faster for spleen and slower for bone marrow).