ASSESSMENT OF THE CORONARY VASODILATOR ACTION OF SK&F 24260 IN THE DOG

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Abstract
SUMMARY: 1. The effects of SK&F 24260 administered intravenously or intraduodenally on the coronary sinus outflow, coronary arteriovenous oxygen difference (A‐V O2), myocardial oxygen consumption (MVO2), systemic blood pressure, heart rate and atrioventricular (AV) conduction time were examined in open‐chest dogs.2. SK&F 24260 in doses of 0.3–10 μg/kg, i.v., caused a dose‐dependent increase in coronary sinus outflow, but the increase was smaller with 30 μg/kg, i.v., than with 10μg/kg, i.v.3. SK&F 24260 (0.3–30μg/kg, i.v.) decreased A‐V O2 and MVO2 in a dose‐dependent manner.4. SK& F 24260 (0.3–30μg/kg, i.v.) decreased systemic blood pressure and heart rate, and increased AV conduction time.5. Intraduodenal administration of SK&F 24260 (1 mg/kg) produced almost the same effects on coronary sinus outflow, A‐V O2, MVO2, systemic blood pressure, heart rate and AV conduction time as did the intravenous administration of the compound (10μg/kg).6. The property of SK&F 24260 to increase the coronary blood flow and to moderately decrease MVO2, systemic blood pressure and heart rate indicates that this agent is a potential antianginal drug.

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