Nuclear analogs of β-lactam antibiotics. XX. Synthesis and X-ray structure determination of exocyclic penems: sulfur analogs of clavulanic acid
- 1 November 1984
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 62 (11) , 2282-2286
- https://doi.org/10.1139/v84-388
Abstract
Penems 5 were converted to exocyclic analogs 6 and 10. These served as substrates for conversion to the sulfone 11 and oxopenam 12. None of the products showed any activity as antibiotics or as β-lactamase inhibitors. A single cyrstal X-ray diffraction analysis of compound 6a verified the exocyclic penem structure.This publication has 1 reference indexed in Scilit:
- The penems, a new class of .beta.-lactam antibiotics. 2. Total synthesis of racemic 6-unsubstituted representativesJournal of the American Chemical Society, 1979