A Quantitative Study of Cholinergic-Dopaminergic Interactions in the Central Nervous System
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 24 (4) , 222-229
- https://doi.org/10.1159/000137600
Abstract
The effects of cholinergic (Ach) and anti-Ach drugs on stereotyped behavior induced by apomoφhine administration were studied quantitatively. Dose-response curves were constructed to apomoφhine and the horizontal shifts of the experimental curves induced by the different treatments were measured at the level of ED50 of apomoφhine. Treatment with both atropine sulfate and scopolamine hydrobromide induced a leftward displacement of the dose-response curve; physostigmine and oxotremorine displaced the curve to the right. Changes in stereotypy were not observed after atropine methyl nitrate. It is concluded that the activity of acetylcholine-containing neurons may exert a modulatory influence on dopaminergic systems.Keywords
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