Synthesis of dl-9(O)-methanoprostaglandin-I1.
- 1 January 1984
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 32 (2) , 424-429
- https://doi.org/10.1248/cpb.32.424
Abstract
The synthesis of both 9(O)-methano-6.alpha.-prostaglandin-I1 (9(O)-methano-6.alpha.-PGI1) and 9(O)-methano-6.beta.-prostaglandin-I1 (9(O)-methano-6.beta.-PGI1) was accomplished via the same synthetic intermediate obtainable from 1,3-cyclooctadiene. These analogs showed weak inhibitory activity in rabbit platelet aggregation induced by ADP. 9(O)-methano-6.beta.-PGI1 did not show any cytoprotective action on rabbit stomach epithelial cells at the concentration of 10-6 M.This publication has 1 reference indexed in Scilit: