Urinary Zinc Excretion during Treatment with Different Diuretics

Publisher Website
Google Scholar
Abstract
Urinary Zn excretion was studied in a randomized trial in 9 patients during treatment with bendroflumethiazide, chlorthalidone and hydrochlorothiazide and in another 9 patients during treatment with bumetanide, furosemide and triamterene. During treatment with the thiazides, the Zn concentration rose by 30% and the total amount of Zn excretion increased by 60%. In contrast, during treatment with the loop-diuretics, urine Zn concentration diminished and the total amount of Zn excretion increased much less than during therapy with the thiazides. With respect to the importance of Zn as an essential element in human metabolism and the frequency of diuretic treatment, the observed increased urinary losses of Zn deserve further attention. [This study has relevance to Zn deficiency disorders.].