Accumulation of Nuclear p53 and Tumor Progression in Bladder Cancer
Open Access
- 10 November 1994
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 331 (19) , 1259-1264
- https://doi.org/10.1056/nejm199411103311903
Abstract
We have previously demonstrated a strong association between nuclear accumulation of p53 protein, as determined by immunohistochemical analysis, and mutations in the p53 gene. The purpose of this study was to determine the relation between nuclear accumulation of p53 and tumor progression in transitional-cell carcinoma of the bladder.Keywords
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