Regional variation in cerebral perfusion during acute hypertension
- 1 January 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 37 (1) , 94
- https://doi.org/10.1212/wnl.37.1.94
Abstract
Regional cerebral blood flow (rCBF) was measured in rats to define the autoregulatory response at different levels of hypertension. Mean arterial blood pressure (MABP) was raised with IV metaraminol. rCBF was measured using 14C-iodoantipyrine. Autoregulation was intact in normotensive animals and those with MABP of 152 to 158 mm Hg. At higher pressures, autoregulation was abnormal and heterogeneous. Hyperperfusion was most prominent in cerebellum, parietal gray matter, thalamus, striatum, and pons. These anatomic sites are recognized sites of hypertensive hemorrhage in humans.This publication has 3 references indexed in Scilit:
- The Harvard Cooperative Stroke RegistryNeurology, 1978
- Cerebral blood flow autoregulation in the rat.Stroke, 1978
- Spontaneous Hemorrhage in the Posterior FossaArchives of Neurology, 1964