SIDE REACTIONS IN PEPTIDE-SYNTHESIS .5. RE-EXAMINATION OF MIXED ANHYDRIDE METHOD

  • 1 January 1977
    • journal article
    • research article
    • Vol. 10  (5) , 380-384
Abstract
Acylation of amino acid .beta.-naphthylamides with protected (tert-butyloxycarbonyl) amino acid-isobutylcarbonic acid mixed anhydrides resulted in each case in the formation of some undesired by-product: an isobutyloxycarbonylamino acid .beta.-naphthylamide. The amount of this 2nd acylation product was particularly high, with the hindered amino acids valine and isoleucine as carboxyl-components. The nature of the amino component had no major influence on the extent of this side reaction.

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