Comparison of Once-Daily versus Twice-Daily Administration of Cefdinir against Typical Bacterial Respiratory Tract Pathogens
Open Access
- 1 October 2001
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (10) , 2936-2938
- https://doi.org/10.1128/aac.45.10.2936-2938.2001
Abstract
In an in vitro pharmacodynamic model, a twice-daily cefdinir dosing regimen was more effective than a once-daily regimen against common bacterial respiratory pathogens in producing 3-log 10 killing and preventing the occurrence of regrowth at 24 h. Twice-daily administration is likely the more appropriate cefdinir dosing strategy for the treatment of community-acquired pneumonia.Keywords
This publication has 7 references indexed in Scilit:
- Pharmacokinetics and pharmacodynamics of antibiotics in otitis mediaThe Pediatric Infectious Disease Journal, 1996
- Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporinsDiagnostic Microbiology and Infectious Disease, 1995
- The Importance of Pharmacokinetic/Pharmacodynamic Surrogate Markers to OutcomeClinical Pharmacokinetics, 1995
- Elimination of quinolone antibiotic carryover through use of antibiotic-removal beadsAntimicrobial Agents and Chemotherapy, 1993
- Assay of 27 antimicrobials using a microbiological method.1983
- Influence of Protein Binding of Antibiotics on Serum Pharmacokinetics and Extravascular Penetration: Clinically Useful ConceptsClinical Infectious Diseases, 1980
- Kinetic model for gentamicin dosing with the use of individual patient parametersClinical Pharmacology & Therapeutics, 1977