An Evaluation of a Once Daily Dosage Régime of Dothiepin Hydrochloride (Prothiaden)
- 1 September 1976
- journal article
- research article
- Published by SAGE Publications in Journal of International Medical Research
- Vol. 4 (5) , 319-325
- https://doi.org/10.1177/030006057600400505
Abstract
This paper reports on the use of a single daily dose of dothiepin hydrochloride (Prothiaden). The results from a metabolism study using [14C] dothiepin were used to calculate the daily variations in blood levels after once daily and thrice daily dose regimes. A clinical study on the use of a single daily dose of 75 mg of dothiepin showed this type of regime to be well tolerated and efficacious in the treatment of 105 depressed patients in general practice. Compared to a thrice daily regime the once daily dose appeared to be more beneficial on symptomatic insomnia during the early treatment period.This publication has 3 references indexed in Scilit:
- The Outcome of Dothiepin Treatment in 1,900 Depressed PatientsInternational Pharmacopsychiatry, 1975
- A Double-Blind Comparison of Three Times Daily and Single Night Dosage of the Tricyclic Anti-Depressant DothiepinJournal of International Medical Research, 1974
- A Brief Rating Scale for antidepressant drug trialsComprehensive Psychiatry, 1971