MembraneiBuffer Partition Coefficient for Ethanol in Dimyristoylphosphatidylcholine
- 1 March 1981
- journal article
- research article
- Published by Wiley in Alcohol, Clinical and Experimental Research
- Vol. 5 (2) , 259-263
- https://doi.org/10.1111/j.1530-0277.1981.tb04899.x
Abstract
It is becoming generally accepted that an important aspect of the mechanism of ethanol intoxication involves physical interactions of ethanol with membrane components. Phase transitions of dimyristoylphosphatidylcholine (DMPC) are followed using optical density measurements, as a function of aqueous ethanol concentration. The shift of the phase transition to lower temperatures is interpreted in terms of the thermodynamics of freezing point depressions. This analysis provides a partition coefficient of ethanol into DMPC of 0.07 l of solution/kg membrane or 2.64 mol of solvent/mol of DMPC.This publication has 28 references indexed in Scilit:
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