Levels of Trimethoprim and Sulfamethoxazole in Human Oviduct Mucosa and Plasma
- 1 January 1982
- journal article
- research article
- Published by Wiley in Acta Obstetricia et Gynecologica Scandinavica
- Vol. 61 (2) , 149-152
- https://doi.org/10.3109/00016348209156546
Abstract
The oviductal and plasma levels of trimethoprim (TMP) and sulfamethoxazole (SMZ) were studied in 9 women after oral and i.v. administration of a drug combination (EusaprimR, Wellcome Foundation Ltd.). The concentration of TMP in a healthy endosalpinx was found to be twice as high (4.7 μg/g, range 2.8–8.3) as in plasma (2.6 μg/ml, range 2.1–3.6). Conversely, the endosalpingeal level of SMZ (38 μg/g, range 12–65) was about half that in plasma (77 μg/ml, range 58–95). The agar well diffusion method was used for the concentration determinations. The specimens were collected during surgery for non-infectious genital diseases. The implication of treatment by the given drugs is discussed.This publication has 8 references indexed in Scilit:
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