Alterations in pulmonary mechanics with airway obstruction during rest and exercise

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Abstract
The effects of artificial expiratory airway obstruction on pulmonary compliance, work of breathing, and pressure-flow relationships have been studied in five normal young males at rest and during treadmill exercise. The finding of a significant decrease in compliance during resistance breathing strongly suggests that alterations in pulmonary blood volume have occurred. In addition, there is evidence that uniformity of gas distribution within the lung has been impaired, a finding which is consonant with previously studied changes in lung volumes secondary to the obstruction. expiratory airway obstruction; compliance; work of breathing; pulmonary mechanics during exercise; resistance breathing during exercise Submitted on October 8, 1964