Network Adaptation Improves Temporal Representation of Naturalistic Stimuli in Drosophila Eye: II Mechanisms
Open Access
- 30 January 2009
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 4 (1) , e4306
- https://doi.org/10.1371/journal.pone.0004306
Abstract
Retinal networks must adapt constantly to best present the ever changing visual world to the brain. Here we test the hypothesis that adaptation is a result of different mechanisms at several synaptic connections within the network. In a companion paper (Part I), we showed that adaptation in the photoreceptors (R1–R6) and large monopolar cells (LMC) of the Drosophila eye improves sensitivity to under-represented signals in seconds by enhancing both the amplitude and frequency distribution of LMCs' voltage responses to repeated naturalistic contrast series. In this paper, we show that such adaptation needs both the light-mediated conductance and feedback-mediated synaptic conductance. A faulty feedforward pathway in histamine receptor mutant flies speeds up the LMC output, mimicking extreme light adaptation. A faulty feedback pathway from L2 LMCs to photoreceptors slows down the LMC output, mimicking dark adaptation. These results underline the importance of network adaptation for efficient coding, and as a mechanism for selectively regulating the size and speed of signals in neurons. We suggest that concert action of many different mechanisms and neural connections are responsible for adaptation to visual stimuli. Further, our results demonstrate the need for detailed circuit reconstructions like that of the Drosophila lamina, to understand how networks process information.Keywords
This publication has 35 references indexed in Scilit:
- Network Adaptation Improves Temporal Representation of Naturalistic Stimuli in Drosophila Eye: I DynamicsPLOS ONE, 2009
- The Neural Substrate of Spectral Preference in DrosophilaNeuron, 2008
- Synaptic circuits of the Drosophila optic lobe: The input terminals to the medullaJournal of Comparative Neurology, 2008
- Glutamate, GABA and Acetylcholine Signaling Components in the Lamina of the Drosophila Visual SystemPLOS ONE, 2008
- Histamine and Its Receptors Modulate Temperature-Preference Behaviors inDrosophilaJournal of Neuroscience, 2006
- Feedback Network Controls Photoreceptor Output at the Layer of First Visual Synapses in Drosophila The Journal of general physiology, 2006
- Robustness of Neural Coding inDrosophilaPhotoreceptors in the Absence of Slow Delayed Rectifier K+ChannelsJournal of Neuroscience, 2006
- Impact of Rearing Conditions and Short-Term Light Exposure on Signaling Performance inDrosophilaPhotoreceptorsJournal of Neurophysiology, 2004
- Chemical neuroanatomy of the fly's movement detection pathwayJournal of Comparative Neurology, 2003
- The Rate of Information Transfer of Naturalistic Stimulation by Graded PotentialsThe Journal of general physiology, 2003